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Age related sarcopenia and its related loss in strength and endurance are a part of the aging process, as are things involved with cognitive performance. There is an increased incidence of certain neurodegenerative diseases seen as we age, as well- things like Parkinson’s and others related. Over the last several years, much more research has been devoted to the potential usage of creatine to help in all of these matters related to aging and neurodegenerative problems. Frailty Syndrome has become an increasingly recognized predictor of morbidity and mortality in older individuals. There are several components to this syndrome, including sarcopenia (muscle wasting), osteoporosis, muscle weakness, fatigue, and weight loss being other aspects. Creatine is being looked at as a possible part of the therapy to fight against this serious health problem [Altern. Med Rev. 2007; 12(3):246-258].

A number of published clinical studies are demonstrating positive findings for the use of creatine in the elderly. In one such study, a 14 day course of creatine in men and women (ages 64-86) was found to increase upper body grip strength and increase physical working capacity by delaying neuromuscular fatigue, which may be important for maintaining health and independent living in the elderly [J Nutr Health Aging. 2007; 11(6):459-64]. Another study demonstrated that oral creatine increases the anaerobic power and work capacity of sedentary elderly during maximum pedaling tasks, while, yet another study on the elderly shows that creatine plus resistance training enhanced the resistance exercise mediated gains in fat-free mass and strength [Appl Physiol Nutr Metab. 2008; 33(1):213-27].

This is thought to possibly result from a shift in the proportion of mtDNA genotype towards that of a younger adult subsequent to its activation of satellite cells. On the down side, it has been seen that older individuals have a smaller increase in muscle phosphorcreatine after supplementation as compared to younger adults. However, a more recent study suggests that the timing of the ingestion of the creatine in the elderly has an important impact. Taking the creatine near the time of the resistance training sessions may be more beneficial for increasing muscle mass and strength than ingestion at other times of the day [Appl Physiol Nutr Metab. 2008; 33(1): 184-90].